Population
Male Wister-Kyoto rats (n=10)
Comparison
Water deprivation for 72 hours with free access… vs Control rats
Design
Preclinical
Follow-up
72 hours
Authors
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These rodent results should not alter clinical practice; leaves open human validation of s(P)RR in volume status.
Water deprivation in rats decreases plasma s(P)RR concentrations while increasing renal full-length (P)RR levels, likely via reduced furin expression.
Tamura et al. (2016) studied this question.
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