Key result
Even with combined renal denervation and adrenal demedullation, 48 hours of water deprivation significantly increased plasma renin activity from 1.8 to 6.8 ng/ml/h (P < 0.05).
Population
Male Sprague-Dawley rats, conscious and unrestrained
Comparison
48 hours of water deprivation, with or without… vs Intact or sham-operated rats, and basal state
Design
Preclinical
Follow-up
48 hours
Authors
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Renin activation persists after sympathoadrenomedullary ablation during dehydration in rats; leaves open non-neural mechanisms for study.
Absolute Event Rate: 6.8% vs 1.8%
p-value: p=< 0.05
Sympathoadrenomedullary activation is not the sole mechanism mediating increased plasma renin activity during water deprivation in rats.
Blair et al. (1997) studied Water deprivation. Water deprivation vs. Basal state (control) was evaluated on Plasma renin activity (PRA) (p=< 0.05). Even with combined renal denervation and adrenal demedullation, 48 hours of water deprivation significantly increased plasma renin activity from 1.8 to 6.8 ng/ml/h (P < 0.05).
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