Key result
Combined administration of ANG II and AVP receptor antagonists in dehydrated rabbits produced significant decreases in MAP (-9 mmHg) and hindquarters resistance (-24%), and increases in RSNA (117%).
Population
Conscious water-deprived rabbits
Comparison
Angiotensin II receptor antagonist and/or AVP-V1… vs Water-replete state and baseline dehydrated state
Design
Preclinical
Authors
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Supports hormonal compensation for MAP in dehydrated animal models; leaves open translation to human physiology or practice.
In dehydrated rabbits, angiotensin II and vasopressin pressor mechanisms are activated to sustain arterial pressure, while sympathetic nerve activity increases to maintain peripheral resistance when these receptors are blocked.
Trapani et al. (1988) studied Dehydration. ANG II receptor antagonist and AVP-V1 antagonist vs. Water-replete state / baseline was evaluated on Arterial pressure (MAP), heart rate (HR), renal sympathetic nerve activity (RSNA), and regional hemodynamics. Combined administration of ANG II and AVP receptor antagonists in dehydrated rabbits produced significant decreases in MAP (-9 mmHg) and hindquarters resistance (-24%), and increases in RSNA (117%).
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