Key result
Administration of angiotensin II antagonists caused a significant decrease in mean arterial pressure in dehydrated rabbits (-16 to -19 mmHg) but not in water-replete rabbits (-1 to -4 mmHg).
Why the study?
Do angiotensin II antagonists reduce mean arterial pressure in dehydrated rabbits with or without baroreceptor reflexes?
Population
Awake rabbits, either sham-operated or baroreceptor-denervated, in normal water-replete state or after 6…
Comparison
Angiotensin II antagonists vs Water-replete state vs dehydrated state
Design
Preclinical
Authors
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Highlights dehydration-specific BP effects of angiotensin II blockade in rabbits; leaves open translation to human hypovolemia.
Do angiotensin II antagonists reduce mean arterial pressure in dehydrated rabbits with or without baroreceptor reflexes?
Angiotensin II plays an important role in blood pressure regulation during a high-renin, dehydrated state, but not during a normal renin, water-replete state, regardless of baroreceptor reflex intactness.
Trippodo et al. (1977) studied Dehydration and baroreceptor denervation. Angiotensin II antagonists vs. Water-replete state was evaluated on Mean arterial pressure. Administration of angiotensin II antagonists caused a significant decrease in mean arterial pressure in dehydrated rabbits (-16 to -19 mmHg) but not in water-replete rabbits (-1 to -4 mmHg).
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