Key result
Acute inhibition of the PVN by muscimol significantly decreased renal sympathetic nerve activity (-26.7%) and mean arterial blood pressure (-46 mmHg) in water-deprived rats compared to controls.
Why the study?
Does acute inhibition of the PVN with muscimol decrease RSNA and MAP in water-deprived rats?
Population
Urethane-alpha-chloralose-anesthetized rats deprived of water but not food for 48 h and control rats
Comparison
Acute inhibition of the hypothalamic… vs Control rats receiving muscimol, and…
Design
Preclinical
Authors
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PVN inhibition effects on RSNA/MAP in dehydrated rats remain preclinical; leaves open human relevance in volume depletion.
Does acute inhibition of the PVN with muscimol decrease RSNA and MAP in water-deprived rats?
Sympathetic outflow contributes more to the maintenance of blood pressure in water-deprived rats, dependent partly on ongoing PVN neuronal activity.
Stocker et al. (2004) studied Water deprivation (n=14). Bilateral microinjection of the GABA(A) agonist muscimol into the PVN vs. Control rats (not water-deprived) and isotonic saline vehicle was evaluated on Renal sympathetic nerve activity (RSNA) and mean arterial blood pressure (MAP). Acute inhibition of the PVN by muscimol significantly decreased renal sympathetic nerve activity (-26.7%) and mean arterial blood pressure (-46 mmHg) in water-deprived rats compared to controls.