Why the study?
Does sympathetic blockade or regional denervation attenuate the increase in mean arterial pressure induced by water deprivation in conscious rats?
Population
Conscious rats chronically instrumented with a radiotelemetry transmitter and an indwelling venous catheter
Comparison
Chronic blockade of α/β-adrenergic receptors… vs Control groups undergoing 48 hours of water…
Design
Preclinical
Follow-up
48 hours
Authors
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Adrenal and combined adrenergic blockade blunt dehydration hypertension in rats; hypothesis-generating for sympathetic-adrenal mechanisms but leaves open clinical translation.
Does sympathetic blockade or regional denervation attenuate the increase in mean arterial pressure induced by water deprivation in conscious rats?
In conscious rats, the sympathetic nervous system contributes to water deprivation-induced increases in mean arterial pressure, a response that appears linked to adrenocortical hormones rather than targeted sympathetic nerve activity to a specific vascular bed.
Veitenheimer et al. (2012) studied this question.
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