October 1, 1992AJP Regulatory Integrative and Comparative Physiology

Vasopressin and angiotensin II in reflex regulation of heart rate: effect of water deprivation

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Why the study?

Do endogenous angiotensin II and vasopressin enhance baroreflex-mediated increases in heart rate in water-replete and water-deprived dogs?

Population

Water-replete and water-deprived dogs

Comparison

Pretreatment with competitive ANG II antagonist… vs Control state and comparison between…

Design

Preclinical

Authors

VBVirginia L. BrooksOregon Health & Science University

Discussion

Member takes

Implication

Does not inform clinical baroreflex management; leaves open physiological roles of endogenous ANG II and vasopressin in humans.

Structured PICO

Do endogenous angiotensin II and vasopressin enhance baroreflex-mediated increases in heart rate in water-replete and water-deprived dogs?

Population

Water-replete and water-deprived dogs

Intervention

Pretreatment with competitive ANG II antagonist saralasin, a V1-vasopressin antagonist, or a combined V1/V2-vasopressin antagonist, alone or in combination, followed by nitroprusside infusion (0.3, 0.6, 1.5, and 3.0 micrograms.kg-1.min-1)

Comparator

Control state (no antagonist pretreatment) and comparison between water-replete and water-deprived states

Outcome

Heart rate response to hypotension induced by nitroprusside infusionsurrogate

Endogenous vasopressin and angiotensin II play a physiological role in amplifying and maintaining normal baroreflex-mediated tachycardia during hypotension.

Cite This Study

Virginia L. Brooks (1992) studied this question.

synapsesocial.com/papers/6a96dbdf1f16343146bb9597 https://doi.org/10.1152/ajpregu.1992.263.4.r756

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Vasopressin and angiotensin II in reflex regulation of heart rate: effect of water deprivation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vasopressin and angiotensin II in reflex regulation of heart rate: effect of water deprivation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider