January 1, 1995Clinical and Experimental Hypertension

Angiotensin II Induces the Expression of C-FOS mRNA in the Central Nervous System of the Rat

View Full Paper

Ask AI

Bookmark

Population

Conscious rats

Design

Preclinical

Follow-up

Up to 60 minutes

Authors

CLC.J. LebrunKiel University EMEva MöllenhoffKiel University GBGang BaoHarbin Institute of Technology

Discussion

Member takes

Implication

Supports central AT1 role in neuroplasticity from animal data; leaves open human translation and clinical relevance.

Structured PICO

Population

Conscious rats

Intervention

Intracerebroventricular (icv) injections of angiotensin II (1, 10, 100 ng), with or without icv pretreatment with the ANG II-AT1 receptor antagonist losartan

Outcome

Expression of c-fos mRNA in the caudate nucleus, hypothalamus, midbrain and brainstemsurrogate

Central periventricular AT1 receptor stimulation by angiotensin II induces c-fos mRNA expression in the brain, suggesting a role in neuroplastic processes.

Cite This Study

Lebrun et al. (1995) studied this question.

synapsesocial.com/papers/6a855e0eb605bb00f9d4c49d https://doi.org/10.3109/10641969509033641

View Full Paper

Ask AI

Bookmark

Angiotensin II Induces the Expression of C-FOS mRNA in the Central Nervous System of the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Induces the Expression of C-FOS mRNA in the Central Nervous System of the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider