Activation of ATP‐dependent K+ channels by metabolic poisoning in adult mouse skeletal muscle: role of intracellular Mg(2+) and pH.

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Population

Adult mouse isolated skeletal muscle fibres

Comparison

Metabolic poisoning, intracellular Mg2+… vs Control conditions

Design

Preclinical

Authors

Discussion

Hypothesis-generating for KATP regulation during metabolic stress; human studies needed before clinical relevance.

Population

Adult mouse isolated skeletal muscle fibres

Intervention

Metabolic poisoning (fluorodinitrobenzene, dinitrophenol, cyanide), intracellular Mg2+ application, and decreased intracellular pH

Comparator

Control conditions (unpoisoned, normal intracellular Mg2+ and pH)

Outcome

ATP-dependent K+ (K+ATP) channel activity and single channel current amplitudesurrogate

Metabolic poisoning activates K+ATP channels in skeletal muscle, a process mediated by increased intracellular Mg2+ and decreased pH.

Allard et al. (1995) studied this question.

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