Population
Excised inside-out patches of ATP-dependent K+ channels from rat flexor digitorum brevis muscle
Comparison
Intracellular anions applied to the cytoplasmic… vs 139 mM Cl- internal solution
Design
Preclinical
Authors
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May guide KATP channel patch-clamp protocols; leaves open physiological roles in intact muscle.
Intracellular anions such as gluconate stabilize the structure of ATP-dependent K+ channels in rat skeletal muscle, restoring activity and preventing run-down.
McKillen et al. (1994) studied this question.
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