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December 1, 1991AJP Regulatory Integrative and Comparative Physiology

Heart rate variability as a measure of autonomic function during weight change in humans

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Why the study?

Does experimentally induced weight change alter autonomic function as measured by heart rate variability in humans?

Population

10 human subjects undergoing experimentally induced weight changes

Comparison

Experimentally induced weight increase and… vs Usual or starting body weight

Design

Other

Authors

JHJoy HirschUniversité Claude Bernard Lyon 1RLRudolph L. LeibelVassar CollegeRMRonald M. MackintoshRockefeller University

Discussion

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Overview

Weight gain may reduce parasympathetic tone and elevate arrhythmia risk; hypothesis-generating and requires larger prospective confirmation.

Structured PICO

Does experimentally induced weight change alter autonomic function as measured by heart rate variability in humans?

P
Population
10 human subjects (7 initial, 3 additional tested at constant respiratory rate) undergoing experimentally induced weight changes
I
Intervention
Experimentally induced weight increase (10% above usual or starting weight) and weight reduction
C
Comparator
Usual or starting body weight
O
Outcome
Autonomic function evaluated by spectral analysis of heart rate variability (HRV) and mean heart ratesurrogate

Experimentally induced weight gain decreases parasympathetic tone, providing a potential physiological mechanism for obesity-related arrhythmias and cardiac alterations.

Cite This Study

Hirsch et al. (1991) studied this question.

synapsesocial.com/papers/6a855e4ad1e5e0588dd4cfc3https://doi.org/10.1152/ajpregu.1991.261.6.r1418
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Also Consider

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