December 1, 1959Acta Physiologica Scandinavica

Effects of Alterations of Total Muscular Blood Flow on Local Tissue Clearance of Radio‐Iodide in the Cat.

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Population

Anesthetized cats (gastrocnemius muscle model)

Design

Preclinical

Authors

CHChester HymanUniversity of Southern California SRSune RosellHospital de Sant Pau ARAnders RosénLinköping University

Discussion

Member takes

Implication

Hypothesis-generating for hypothalamic selectivity of skeletal muscle shunt flow in felines; leaves open relevance to human cardiovascular regulation.

Structured PICO

Population

Anesthetized cats (gastrocnemius muscle model)

Intervention

Alterations of total muscular blood flow via arterial restriction, sympathetic stimulation, intra-arterial infusion of compound 48/80 or methacholine, sciatic nerve or anterior root stimulation, and stimulation of the vasodilator pathway in the hypothalamus

Outcome

Simultaneous measurement of local tissue clearance of radio-iodide and venous outflow or arterial inflowsurrogate

In a feline skeletal muscle model, active vasodilation driven by hypothalamic stimulation selectively increases shunt flow rather than nutritional blood flow.

Cite This Study

Hyman et al. (1959) studied this question.

synapsesocial.com/papers/6a855ecaa95ccb34714e1f83 https://doi.org/10.1111/j.1748-1716.1959.tb01765.x

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Implication

Hypothesis-generating for hypothalamic selectivity of skeletal muscle shunt flow in felines; leaves open relevance to human cardiovascular regulation.

Effects of Alterations of Total Muscular Blood Flow on Local Tissue Clearance of Radio‐Iodide in the Cat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Alterations of Total Muscular Blood Flow on Local Tissue Clearance of Radio‐Iodide in the Cat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider