What question did this study set out to answer?

To review the pathophysiological mechanisms, strengths, and translational challenges of existing rodent models of spondyloarthritis.

August 19, 2026Journal of AutoimmunityOpen Access

Experimental models of spondyloarthritis: Pathophysiological insights and translational challenges

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Authors

CMC. MorizotCentre Hospitalier Régional et Universitaire de Nancy JHJulia HalperCentre National de la Recherche Scientifique MBM. BrebanInserm

Discussion

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Implication

Review reveals mechanistic insights and translational limitations across rodent models of spondyloarthritis, highlighting strategies to improve clinical translation.

Key Points

To review the pathophysiological mechanisms, strengths, and translational challenges of existing rodent models of spondyloarthritis.
Categorized and analyzed major rodent models representing axial spondyloarthritis, psoriatic arthritis, and inflammatory bowel disease-associated arthritis.
Assessed model fidelity across clinical manifestations, including axial inflammation, enthesitis, peripheral arthritis, uveitis, psoriasis, and gut involvement.
Evaluated emerging translational techniques, including humanized mouse platforms, microbiome engineering, and multi-omic data integration.
Rodent models have defined pivotal SpA mechanisms, notably the gut–joint axis, IL-23-driven entheseal inflammation, and TNF-mediated signaling.
Current individual animal models fail to capture the complete clinical spectrum of human spondyloarthritis and its diverse extra-articular manifestations.
Translational fidelity requires next-generation approaches, such as humanized mouse strains and microbiome modulation, to bridge preclinical discoveries to clinical therapy.

Cite This Study

Morizot et al. (2026) studied this question.

synapsesocial.com/papers/6a85639d03308d306e2d6e78 https://doi.org/10.1016/j.jaut.2026.103607

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August 19, 2026Journal of AutoimmunityOpen Access

Experimental models of spondyloarthritis: Pathophysiological insights and translational challenges

View Full Paper

Ask AI

Bookmark

Authors

CMC. MorizotCentre Hospitalier Régional et Universitaire de Nancy JHJulia HalperCentre National de la Recherche Scientifique MBM. BrebanInserm

Discussion

Member takes

Implication

Review reveals mechanistic insights and translational limitations across rodent models of spondyloarthritis, highlighting strategies to improve clinical translation.

Key Points

To review the pathophysiological mechanisms, strengths, and translational challenges of existing rodent models of spondyloarthritis.
Categorized and analyzed major rodent models representing axial spondyloarthritis, psoriatic arthritis, and inflammatory bowel disease-associated arthritis.
Assessed model fidelity across clinical manifestations, including axial inflammation, enthesitis, peripheral arthritis, uveitis, psoriasis, and gut involvement.
Evaluated emerging translational techniques, including humanized mouse platforms, microbiome engineering, and multi-omic data integration.
Rodent models have defined pivotal SpA mechanisms, notably the gut–joint axis, IL-23-driven entheseal inflammation, and TNF-mediated signaling.
Current individual animal models fail to capture the complete clinical spectrum of human spondyloarthritis and its diverse extra-articular manifestations.
Translational fidelity requires next-generation approaches, such as humanized mouse strains and microbiome modulation, to bridge preclinical discoveries to clinical therapy.

Cite This Study

Morizot et al. (2026) studied this question.

synapsesocial.com/papers/6a85639d03308d306e2d6e78 https://doi.org/10.1016/j.jaut.2026.103607

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