What question did this study set out to answer?

To summarize the ethnopharmacological applications, phytochemical constituents, and underlying molecular mechanisms of Pelargonium graveolens in traditional and modern medicine.

August 19, 2026Applied SciencesOpen Access

Pelargonium graveolens L’Hér. in Traditional and Contemporary Medicine: Phytochemistry, Pharmacology, and Molecular Mechanisms

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Authors

KBKamil Bukowiec MSMateusz Sroka APAgata Pałkiewicz

Discussion

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Overview

Literature review demonstrates broad antimicrobial, anti-inflammatory, and neuromodulatory actions of Pelargonium graveolens, highlighting therapeutic potential requiring clinical standardization.

Key Points

To summarize the ethnopharmacological applications, phytochemical constituents, and underlying molecular mechanisms of Pelargonium graveolens in traditional and modern medicine.
Review of ethnopharmacological literature on Pelargonium graveolens applications across respiratory, digestive, and pain-related conditions.
Synthesis of preclinical and molecular investigations regarding volatile monoterpenes, polyphenols, and essential oil extracts.
Pelargonium graveolens essential oil suppresses inflammation by inhibiting NF-κB and MAPK pathways, alongside mediators such as histamine, prostaglandins, and nitric oxide.
Bioactive compounds like citronellol, geraniol, and myricetin display broad antimicrobial activity against MRSA and Mycobacterium tuberculosis, reduce ACE2 expression, and block calcium channels.
Neuromodulatory effects through the HPA axis and GABAergic system support traditional anxiolytic applications, though clinical adoption remains limited by phytochemical variability and scarce trial data.

Cite This Study

Bukowiec et al. (2026) studied this question.

synapsesocial.com/papers/6a8563d703308d306e2d739f https://doi.org/10.3390/app16168161

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August 19, 2026Applied SciencesOpen Access

Pelargonium graveolens L’Hér. in Traditional and Contemporary Medicine: Phytochemistry, Pharmacology, and Molecular Mechanisms

View Full Paper

Ask AI

Bookmark

Authors

KBKamil Bukowiec MSMateusz Sroka APAgata Pałkiewicz

Discussion

Member takes

Overview

Literature review demonstrates broad antimicrobial, anti-inflammatory, and neuromodulatory actions of Pelargonium graveolens, highlighting therapeutic potential requiring clinical standardization.

Key Points

To summarize the ethnopharmacological applications, phytochemical constituents, and underlying molecular mechanisms of Pelargonium graveolens in traditional and modern medicine.
Review of ethnopharmacological literature on Pelargonium graveolens applications across respiratory, digestive, and pain-related conditions.
Synthesis of preclinical and molecular investigations regarding volatile monoterpenes, polyphenols, and essential oil extracts.
Pelargonium graveolens essential oil suppresses inflammation by inhibiting NF-κB and MAPK pathways, alongside mediators such as histamine, prostaglandins, and nitric oxide.
Bioactive compounds like citronellol, geraniol, and myricetin display broad antimicrobial activity against MRSA and Mycobacterium tuberculosis, reduce ACE2 expression, and block calcium channels.
Neuromodulatory effects through the HPA axis and GABAergic system support traditional anxiolytic applications, though clinical adoption remains limited by phytochemical variability and scarce trial data.

Cite This Study

Bukowiec et al. (2026) studied this question.

synapsesocial.com/papers/6a8563d703308d306e2d739f https://doi.org/10.3390/app16168161

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