Population
Isolated paced hearts from renal hypertensive rats with left ventricular hypertrophy
Comparison
Glucagon and vasoactive intestinal peptide (VIP) vs Isolated paced hearts from strictly matched…
Design
Preclinical
Authors
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Impaired inotropic responses to VIP/glucagon in rat LVH warrant no clinical extrapolation; leaves open whether adenylate cyclase defects extend beyond β-receptors in patients.
Inotropic responsiveness to adenylate cyclase system stimulants (glucagon and VIP) is impaired in left ventricular hypertrophy from renal hypertension, indicating the defect is not restricted to β-adrenergic receptors.
Fouad et al. (1986) studied this question.
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