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August 19, 2026Psychogeriatrics

Toward Precision Neuropsychiatry of Dementia: Neuropsychiatric Symptoms as Multidimensional Clinical Phenotypes

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Authors

SSShunichiro ShinagawaJikei University School of Medicine TNTomoyuki NagataJikei University School of Medicine

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Implication

Review proposes multidimensional phenotyping of neuropsychiatric symptoms in dementia, suggesting biological and contextual stratification optimizes targeted interventions.

Key Points

To introduce a precision neuropsychiatry framework that conceptualizes neuropsychiatric symptoms as multidimensional clinical phenotypes spanning neurobiology, functional status, and psychosocial context.
Reviewed the conceptual transition from behavioral and psychological symptoms of dementia (BPSD) to mild behavioral impairment (MBI) and precision neuropsychiatry.
Synthesized findings from neuroimaging, brain-age paradigms, neuroinflammation, frailty, and Alzheimer's disease biomarkers.
Identified that identical clinical symptom labels arise from divergent neurobiological mechanisms, biological aging processes, and environmental mismatches.
Established a multidimensional stratification model incorporating disease etiology, clinical stage, neural networks, physical vulnerability, and life history.
Emphasized replacing cross-sectional symptom checklists with longitudinal, mechanism-informed models to optimize differential diagnosis and personalized psychogeriatric care.

Cite This Study

Shinagawa et al. (2026) studied this question.

synapsesocial.com/papers/6a8563eb03308d306e2d7623 https://doi.org/10.1111/psyg.70209

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Implication

Review proposes multidimensional phenotyping of neuropsychiatric symptoms in dementia, suggesting biological and contextual stratification optimizes targeted interventions.

Toward Precision Neuropsychiatry of Dementia: Neuropsychiatric Symptoms as Multidimensional Clinical Phenotypes

Discussion

Member takes

Implication

Key Points

Cite This Study

Toward Precision Neuropsychiatry of Dementia: Neuropsychiatric Symptoms as Multidimensional Clinical Phenotypes

Discussion

Member takes

Implication

Key Points

Cite This Study

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