Population
rat ventricular myocytes
Comparison
1 micromol/L colchicine vs control (untreated) myocytes
Design
Preclinical
Authors
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Hypothesis-generating for microtubule effects on myocyte calcium handling; clinical relevance in humans remains undetermined.
Microtubule disruption with colchicine enhances calcium currents and transients in rat ventricular myocytes, likely sharing a common pathway with beta-adrenergic stimulation.
Gómez et al. (2000) studied this question.
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