Why the study?
Does disruption of actin filaments and microtubules inhibit L-type Ca2+ channel current in cultured vascular smooth muscle cells?
Population
Cultured vascular smooth muscle cells (A7r5 cell line)
Comparison
Disruption of actin filaments and microtubules… vs Untreated cells or cells treated with…
Design
Preclinical
Follow-up
1 hour
Authors
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Actin disruption may inhibit L-type Ca2+ current in VSMCs; leaves open effects on vascular tone, requiring in vivo studies.
Does disruption of actin filaments and microtubules inhibit L-type Ca2+ channel current in cultured vascular smooth muscle cells?
Actin filament disruption, but not microtubule disruption, inhibits L-type Ca2+ channel activity in vascular smooth muscle cells.
Nakamura et al. (2000) studied this question.
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