ATP-sensitive K+ channels in rat ventricular myocytes show considerable variation in ATP sensitivity, widening the expected range of internal ATP concentrations that activate these channels.
Substantial heterogeneity in ventricular KATP channel ATP sensitivity; leaves open relevance to human ischemia or arrhythmias.
We show that ATP-sensitive K+ channels of excised inside-out membrane patches of rat ventricular myocytes show considerable variation in their sensitivity to ATP. In 102 different membrane patches IC50 values ranged from 9 to 580 microM ATP and Hill coefficients from 1% to 6.41% of patches showed openings of ATP-sensitive K+ channels in the presence of 1 mM ATP. These results considerably widen the range of internal ATP concentrations over which one might expect activation of the ATP-sensitive K+ current in cardiac myocytes.
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Findlay et al. (1991) studied this question.
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