June 1, 2000The Journal of PhysiologyOpen Access

ATP‐sensitive potassium channels in capillaries isolated from guinea‐pig heart

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Population

Capillaries and cardiomyocytes isolated from guinea-pig heart

Design

Preclinical

Authors

MSMichael Mederos y SchnitzlerPhilipps University of Marburg CDChristian DerstParacelsus Medizinische Privatuniversität JDJürgen DautPhilipps University of Marburg

Discussion

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Implication

Animal data preclude clinical translation; leaves open endothelial KATP roles in human cardiac microvasculature.

Structured PICO

Population

Capillaries and cardiomyocytes isolated from guinea-pig heart

Intervention

Application of K+ channel openers (rilmakalim or diazoxide) or metabolic inhibition (250 microM 2,4-dinitrophenol plus 10 mM deoxyglucose)

Outcome

Expression of KATP channel subunits and electrophysiological response (slope conductance) to K+ channel openers or metabolic inhibitionsurrogate

Capillary endothelial cells from guinea-pig heart express KATP channels composed of SUR2B and Kir6.1 and/or Kir6.2 subunits, which respond to K+ channel openers and metabolic inhibition.

Cite This Study

Schnitzler et al. (2000) studied this question.

synapsesocial.com/papers/6a856933f0d179eaafb55d07 https://doi.org/10.1111/j.1469-7793.2000.t01-1-00307.x

View Full Paper

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ATP‐sensitive potassium channels in capillaries isolated from guinea‐pig heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ATP‐sensitive potassium channels in capillaries isolated from guinea‐pig heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider