Key result
Application of glibenclamide depolarized coronary smooth muscle cells to -37 mV, while cromakalim hyperpolarized them to -71 mV, indicating the presence of glibenclamide-sensitive potassium channels.
Population
Terminal arterioles of 20-50 microns diameter obtained by enzymatic digestion of isolated perfused guinea…
Comparison
Application of glibenclamide or cromakalim vs Control conditions
Design
Preclinical
Authors
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No immediate clinical implications; leaves open KATP channel relevance to human coronary vasoregulation.
Glibenclamide-sensitive potassium channels play a significant role in maintaining the membrane potential of coronary smooth muscle cells in isolated arterioles.
Klieber et al. (1994) studied this question. Glibenclamide and cromakalim vs. Control conditions was evaluated on Resting potential and current-voltage relations. Application of glibenclamide depolarized coronary smooth muscle cells to -37 mV, while cromakalim hyperpolarized them to -71 mV, indicating the presence of glibenclamide-sensitive potassium channels.
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