Why the study?
Does lipopolysaccharide treatment or sodium balance alter urinary angiotensinogen excretion in rats?
Population
Rats (n=8 for baseline measurement)
Comparison
Lipopolysaccharide injection or sodium… vs Baseline/control
Design
Preclinical
Follow-up
24 hours
Authors
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May reflect acute inflammation in rats independent of sodium status; hypothesis-generating for human biomarker validation.
Does lipopolysaccharide treatment or sodium balance alter urinary angiotensinogen excretion in rats?
Angiotensinogen is present in rat urine and its excretion increases significantly during acute inflammation induced by lipopolysaccharide, likely derived from plasma.
Yoshiya et al. (1991) studied this question.
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