Population
Cultured murine HL-5 atrial cardiomyocytes (n=51)
Comparison
Whole cell patch-clamp techniques and… vs Adult mouse cardiomyocytes
Design
Preclinical
Authors
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Urges caution using HL-5 cells as mature cardiomyocyte models; leaves open their validity for adult cardiac electrophysiology research.
HL-5 murine atrial cardiomyocytes exhibit significant electrophysiological heterogeneity and an immature action potential phenotype, which is important context for their use in cellular and molecular studies.
Xiao et al. (2006) studied this question.
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