Population
Atrial-derived cell line HL-1, freshly isolated atrial mouse cardiomyocytes, and HEK cell line expressing…
Comparison
Electrophysiological characterization using… vs Freshly isolated atrial mouse cardiomyocytes and…
Design
Preclinical
Authors
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Supports HL-1 cells as a model for IKACh studies; leaves open translation to human atrial electrophysiology.
HL-1 cells demonstrate electrophysiological properties and kinetics comparable to native mouse atrial cardiomyocytes, validating them as a suitable model for studying the I(KACh) current.
Nobles et al. (2010) studied this question.
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