December 1, 2000Journal of Clinical InvestigationOpen Access

Lack of angiotensin II–facilitated erythropoiesis causes anemia in angiotensin-converting enzyme–deficient mice

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Why the study?

Does angiotensin II infusion improve hematocrit in ACE knockout mice?

Population

Two strains of angiotensin-converting enzyme (ACE) knockout mice

Comparison

Infusion of angiotensin II for 2 weeks vs Untreated ACE knockout mice (implied)

Design

Preclinical

Follow-up

2 weeks

Authors

JCJustin M. ColeUniversity of South Florida DEDilek ErtoyKoç University HLHsin‐Chen LinTaichung Veterans General Hospital

Discussion

Member takes

Implication

Supports angiotensin II role in erythropoiesis; hypothesis-generating for anemia mechanisms with ACE inhibitors.

Structured PICO

Does angiotensin II infusion improve hematocrit in ACE knockout mice?

Population

Two strains of angiotensin-converting enzyme (ACE) knockout mice

Intervention

Infusion of angiotensin II for 2 weeks

Comparator

Untreated ACE knockout mice (implied)

Outcome

Hematocrit levelssurrogate

Angiotensin II facilitates erythropoiesis, providing a mechanistic explanation for the reduced hematocrit observed in patients treated with ACE inhibitors.

Cite This Study

Cole et al. (2000) studied this question.

synapsesocial.com/papers/6a856aa211a1f3349d109bff https://doi.org/10.1172/jci10557

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Ask AI

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Lack of angiotensin II–facilitated erythropoiesis causes anemia in angiotensin-converting enzyme–deficient mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lack of angiotensin II–facilitated erythropoiesis causes anemia in angiotensin-converting enzyme–deficient mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider