Population
Angiotensin converting enzyme germline null mutant mice, heterozygous, and wild-type
Comparison
Chronic ACE deficiency and acute infusion of ANG… vs Wild-type mice (+/+) and heterozygous mice (+/-)
Design
Preclinical
Authors
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ANG II is required for TGF in mice; leaves open its necessity for human macula densa signaling.
The absence of tubuloglomerular feedback responses in ACE null mutant mice and their restoration during acute ANG II infusion demonstrates that ANG II is an essential component in the signal transmission pathway linking the macula densa with the glomerular vascular pole.
Traynor et al. (1999) studied this question.
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