Why the study?
Does GW501516 induce endothelial cell proliferation and angiogenesis in endothelial cell models?
Population
Primary human umbilical and aortic endothelial cells, endothelial cell line EAHy926, murine aortic vessels…
Comparison
GW501516 (selective PPARbeta/delta ligand) vs Control
Design
Preclinical
Authors
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May caution against GW501516 in dyslipidemia; leaves open clinical relevance of VEGF-mediated angiogenesis.
Does GW501516 induce endothelial cell proliferation and angiogenesis in endothelial cell models?
Activation of PPARbeta/delta by GW501516 induces endothelial cell proliferation and angiogenesis via VEGF, highlighting a potential safety concern for its use in treating dyslipidemia.
Piqueras et al. (2006) studied this question.
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