Key result
Incorporating age variation in genetic effects identified 26 linkage peaks for blood pressure with maximum LOD scores between 3.0 and 4.6, demonstrating that genetic effects vary by age.
Population
Participants in the Hypertension Genetic Epidemiology Network
Design
Other
Authors
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Supports modeling age in BP genetic linkage studies; leaves open clinical relevance of these loci.
Observational
Yes
Effect estimate: LOD scores 3.0-4.6
Incorporating age variation in genetic effects substantially improves linkage evidence for blood pressure, demonstrating that genetic effects on blood pressure vary by age.
Shi et al. (2008) conducted an observational in Blood pressure. Age variation in genetic effects was evaluated on Linkage peaks for systolic and diastolic blood pressures (LOD scores 3.0-4.6). Incorporating age variation in genetic effects identified 26 linkage peaks for blood pressure with maximum LOD scores between 3.0 and 4.6, demonstrating that genetic effects vary by age.
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