Key result
Circumferential strain from DENSE detected myocardial segments with >50% scar transmurality with a significantly higher area under the curve (0.87) than tagging (0.83) and feature tracking (0.66).
Why the study?
Several CMR techniques measure myocardial strain and torsion accurately, but their relative performance for assessing myocardial function and infarct scar burden needed comparison.
Does CMR using DENSE or tagging improve the detection of myocardial scar compared to feature tracking in patients with suspected coronary artery disease?
Population
116 patients with a high likelihood of coronary artery disease
Comparison
DENSE vs tagging vs feature tracking
Design
Comparative imaging study
Authors
Loading...
DENSE may aid scar detection over feature tracking in suspected CAD; extends strain comparisons but leaves clinical adoption open.
Cross-Sectional (n=116)
Single-blind
No
Does CMR using DENSE or tagging improve the detection of myocardial scar compared to feature tracking in patients with suspected coronary artery disease?
Effect estimate: AUC 0.87
Absolute Event Rate: 0.87% vs 0.83%
p-value: p=0.03 vs tagging, <0.001 vs FT
CMR using DENSE provides superior diagnostic accuracy for detecting regional myocardial scar compared to tagging and feature tracking in patients with suspected coronary artery disease.
Kihlberg et al. (2020) conducted a cross-sectional in Suspected coronary artery disease (n=116). DENSE cardiovascular magnetic resonance vs. Tagging and feature tracking CMR was evaluated on Detection of myocardial segments with >50% late gadolinium enhancement transmurality using segmental circumferential strain (AUC 0.87, p=0.03 vs tagging, <0.001 vs FT). Circumferential strain from DENSE detected myocardial segments with >50% scar transmurality with a significantly higher area under the curve (0.87) than tagging (0.83) and feature tracking (0.66).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: