Key result
Each increment unit in logarithmic pan-immune-inflammation value was independently associated with a 34% increased risk of heart failure occurrence (OR 1.34).
Why the study?
The association between the pan-immune-inflammation value and heart failure outcomes was not well understood in a nationally representative population.
Is elevated pan-immune-inflammation value associated with an increased risk of heart failure occurrence in US adults?
Cross-Sectional (n=11,504)
Is elevated pan-immune-inflammation value associated with an increased risk of heart failure occurrence in US adults?
Odds Ratio: 1.34 (95% CI 1.14–1.58)
p-value: p=0.0004
Elevated pan-immune-inflammation value is independently associated with an increased risk of heart failure occurrence, with a critical threshold identified at a logarithmic value of 5.98.
Does not support clinical adoption of pan-immune-inflammation value; leaves open its prognostic utility in heart failure.
ObjectiveThis study aimed to explore the association between pan-immune-inflammation value and heart failure outcomes using data from the nationally representative National Health and Nutrition Examination Survey database.MethodsWe conduct a cross-sectional cohort analysis using National Health and Nutrition Examination Survey data, including participants aged ≥20 years with available pan-immune-inflammation value data. We performed smooth curve fitting and threshold analysis, using both linear and non-linear regression models, to assess dose-response relationship and explore the continuous effect of pan-immune-inflammation value on heart failure outcomes.ResultsOur analysis revealed a significant and independent non-linear association between elevated pan-immune-inflammation value levels and an increased risk of heart failure occurrence. After adjustment for multiple covariates, these findings remained consistent and each increment unit in logarithmic pan-immune-inflammation value is associated with 34% increase in the risk of heart failure occurrence. Furthermore, we identified an inflection point of logarithmic pan-immune-inflammation value = 5.98 as a critical threshold. Stratified analyses revealed that the association between pan-immune-inflammation value and heart failure occurrence remains consistent across different subgroups.ConclusionsThis study confirmed the clinical value of pan-immune-inflammation value as a novel inflammatory biomarker in the assessment and monitoring of heart failure.
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Yijie Mao (2025) conducted a cross-sectional in Heart failure (n=11,504). Elevated pan-immune-inflammation value (PIV) vs. Lower pan-immune-inflammation value was evaluated on Heart failure occurrence (OR 1.34, 95% CI 1.14-1.58, p=0.0004). Each increment unit in logarithmic pan-immune-inflammation value was independently associated with a 34% increased risk of heart failure occurrence (OR 1.34).
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