Key result
Patients with acute ischemic stroke who had both elevated NT-pro-BNP levels (>1,583.50 pg/mL) and NIHSS scores (>12.5) had a substantially higher in-hospital mortality rate (89.47% vs. 9.84%).
Observational (n=122)
No
Odds Ratio: 5.001 (95% CI 1.233–20.287)
Absolute Event Rate: 37.5% vs 6.76%
p-value: p=0.024
The combination of elevated NT-pro-BNP levels and high NIHSS scores on admission provides independent and incremental prognostic value for predicting in-hospital mortality in patients with acute ischemic stroke.
OBJECTIVE: Determining the prognoses of patients with acute ischemic stroke is difficult. Therefore, the aim of this study was to evaluate whether the combined assessment of plasma N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and the National Institutes of Health Stroke Scale (NIHSS) variables is relevant to the prognosis of patients with acute cerebral ischemic infarction in-hospital. METHODS: We enrolled 122 patients who were within three days of onset of acute ischemic stroke. We measured the plasma NT-pro-BNP level of each patient within 72 hours and recorded the NIHSS score on admission. The factors associated with death were investigated using a multivariate logistic regression analysis. RESULTS: Twenty-three patients (18.85%) died during hospitalization. The frequency of atrial fibrillation (AF), the NIHSS score on admission (8.69±4.87 in the survival group vs. 14.48±2.54 in the deceased group, p<0.001) and the plasma NT-pro-BNP level (median: 926.30 pg/mL in the survival group vs. 3,280 pg/mL in the deceased group, p<0.001; Lg NT-pro-BNP 2.82±0.66 in the survival group vs. 3.46±0.52 in the deceased group, p<0.001) were each significantly higher in the deceased group than in the survival group. The optimal cut-off levels for the NT-pro-BNP level and NIHSS score to distinguish the deceased group from the survival group were 1,583.50 pg/mL and 12.5, respectively. Patients with both elevated NT-pro-BNP levels (>1,583.50 pg/mL) and NIHSS scores on admission (NIHSS >12.5) had a substantially higher mortality rate than those without elevated NT-pro-BNP levels and NIHSS scores (89.47% vs. 9.84%, p<0.001). A multivariate logistic regression analysis demonstrated that a NT-pro-BNP level >1,583.50 pg/mL (OR, 5.001; 95% CI, 1.233 to 20.287, p=0.024) and a NIHSS score >12.5 (OR, 1.465; 95% CI, 1.191 to 1.801, p<0.001) were each independent factors associated with in-hospital death. CONCLUSION: The plasma NT-pro-BNP level and the NIHSS score added independent and incremental contributions to the prognostic stratification of patients with acute ischemic stroke.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2012) conducted an observational in Acute ischemic stroke (n=122). Elevated NT-pro-BNP (>1,583.50 pg/mL) vs. NT-pro-BNP ≤1,583.50 pg/mL was evaluated on In-hospital death (OR 5.001, 95% CI 1.233 to 20.287, p=0.024). Patients with acute ischemic stroke who had both elevated NT-pro-BNP levels (>1,583.50 pg/mL) and NIHSS scores (>12.5) had a substantially higher in-hospital mortality rate (89.47% vs. 9.84%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: