Population
In vitro model using human, rat, dog, pig, and monkey plasma renin
Design
Preclinical
Authors
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These modifications merit in vivo testing; leaves open whether optimized analogues can advance as renin inhibitors.
Specific structural modifications to pepstatin analogues yield compounds with high inhibitory potency against human plasma renin activity in vitro.
Guegan et al. (1986) studied this question.
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