Why the study?
Does pepstatinyl-arginine-O-methyl ester reduce blood pressure in renal hypertensive rats compared to Sar1, Ala8-angiotensin II?
Population
In vitro models (purified hog renin and substrates) and in vivo renal hypertensive rats
Comparison
Pepstatinyl-arginine-O-methyl ester vs Pepstatin A, arginine salt of pepstatin A, and…
Design
Preclinical
Authors
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Renin inhibition matches angiotensin blockade in rats; leaves open translation to human hypertension.
Does pepstatinyl-arginine-O-methyl ester reduce blood pressure in renal hypertensive rats compared to Sar1, Ala8-angiotensin II?
Pepstatinyl-arginine-O-methyl ester is a water-soluble pepstatin A derivative that effectively inhibits the renin-angiotensin system and reduces blood pressure in hypertensive rats.
Evin et al. (1978) studied this question.
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