What question did this study set out to answer?

The aim is to synthesize pepstatin analogs and evaluate their inhibitory effects on pepsin and renin.

Synthesis of analogs of the carboxyl protease inhibitor pepstatin. Effect of structure on inhibition of pepsin and renin

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Synthesis of pepstatin analogs demonstrates structural effects on pepsin and renin inhibition, suggesting design implications.

The aim is to synthesize pepstatin analogs and evaluate their inhibitory effects on pepsin and renin.
Synthesize analogues from N-(tert-butoxycarbonyl)-4-amino-3-hydroxy-6-methylheptanoic acid (Boc-Sta).
Determine inhibition effects on pepsin and renin.
Establish stereochemistry of synthesized compounds.
Iva-Val-(3S,4S)-Sta-Ala-NHiC5H11 inhibits pepsin with Ki = 1 x 10(-9) M.
Iva-Val-(3S,4S)-AHPPA-Ala-NHiC5H11 inhibits pepsin with Ki = 0.9 x 10(-9) M.
Diminishing chirality or peptide chain length reduces binding to pepsin over 100-fold.

Rich et al. (1980) studied this question.

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