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July 12, 2005Circulation

Eight-Year Follow-Up of Patients With Permanent Vena Cava Filters in the Prevention of Pulmonary Embolism

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Why the study?

Do permanent vena cava filters reduce the risk of pulmonary embolism and improve survival in patients with proximal deep-vein thrombosis?

Population

400 patients with proximal deep-vein thrombosis with or without pulmonary embolism

Comparison

Permanent vena cava filter in addition to… vs Standard anticoagulant treatment for at least 3…

Design

RCT, Randomized, Events reviewed blindly by an independent committee

Follow-up

8 years

Discussion

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Implication

Supports avoiding routine filters in proximal DVT; reinforces PE reduction offset by higher DVT without survival benefit.

Structured PICO

Do permanent vena cava filters reduce the risk of pulmonary embolism and improve survival in patients with proximal deep-vein thrombosis?

P
Population
400 patients with proximal deep-vein thrombosis with or without pulmonary embolism
I
Intervention
Permanent vena cava filter in addition to standard anticoagulant treatment for at least 3 months
C
Comparator
Standard anticoagulant treatment for at least 3 months without a vena cava filter
O
Outcome
Symptomatic pulmonary embolism, deep-vein thrombosis, postthrombotic syndrome, and overall survival at 8 yearshard clinical

Permanent vena cava filters reduce the long-term risk of pulmonary embolism but increase the risk of deep-vein thrombosis without improving survival, suggesting they should not be used systematically in general VTE patients.

Cite This Study

A 2005 study studied this question.

synapsesocial.com/papers/6a858f208018c50ef23da920https://doi.org/10.1161/circulationaha.104.512834

Topics

Pulmonary embolism
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Epidemiology of Venous Thromboembolism in the Community2001 · 575 citations
  2. 2Recurrence of pulmonary embolism during anticoagulant treatment: a prospective study.1987 · 48 citations
  3. 3Long-Term, Low-Intensity Warfarin Therapy for the Prevention of Recurrent Venous Thromboembolism2003 · 812 citations
  4. 4Incidence of Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Embolism2004 · 1,840 citations
  5. 5The Long-Term Clinical Course of Acute Deep Venous Thrombosis1996 · 2,117 citations