April 1, 2000Cardiovascular ResearchOpen Access

Effects of ambasilide, quinidine, flecainide and verapamil on ultra-rapid delayed rectifier potassium currents in canine atrial myocytes

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Population

Isolated canine atrial myocytes

Design

Preclinical

Authors

LYLixia YueElectrophysiology

Discussion

Member takes

Implication

Hypothesis-generating in canine myocytes; leaves open translation to human AF therapy.

Structured PICO

Population

Isolated canine atrial myocytes

Intervention

Ambasilide, quinidine, flecainide and verapamil at multiple concentrations

Outcome

Inhibition of ultra-rapid delayed rectifier potassium current (I(Kur.d))surrogate

Ambasilide, quinidine, flecainide, and verapamil inhibit the ultra-rapid delayed rectifier potassium current in canine atrial myocytes, primarily via open-channel blockade.

Cite This Study

Lixia Yue (2000) studied this question.

synapsesocial.com/papers/6a85910f37bcb8373dadabc4 https://doi.org/10.1016/s0008-6363(99)00430-7

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Effects of ambasilide, quinidine, flecainide and verapamil on ultra-rapid delayed rectifier potassium currents in canine atrial myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of ambasilide, quinidine, flecainide and verapamil on ultra-rapid delayed rectifier potassium currents in canine atrial myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider