Key result
Antiarrhythmic drugs preferentially suppressed conduction at the area of slow conduction, terminating atrial flutter in 23 of 24 dogs and causing conduction block in 92% of the dogs.
Why the study?
Do antiarrhythmic drugs preferentially suppress conduction at the area of slow conduction in a canine model of atrial flutter?
Do antiarrhythmic drugs preferentially suppress conduction at the area of slow conduction in a canine model of atrial flutter?
Antiarrhythmic drugs terminate atrial flutter by preferentially producing conduction block at the area of slow conduction in the re-entrant circuit, regardless of their specific electrophysiological class.
Extends mechanistic understanding of flutter termination in reentry; leaves open human translation and clinical relevance.
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Inoue et al. (1991) studied Atrial flutter (n=24). Disopyramide, flecainide, and E-4031 was evaluated on Termination of atrial flutter and conduction block at the area of slow conduction. Antiarrhythmic drugs preferentially suppressed conduction at the area of slow conduction, terminating atrial flutter in 23 of 24 dogs and causing conduction block in 92% of the dogs.
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