Key result
A pulse wave velocity cutoff of 10.35 m/s predicted contrast-induced nephropathy in stable CAD patients undergoing PCI (sensitivity 82.1%, specificity 77.9%, P<.001).
Why the study?
Does increased aortic stiffness predict contrast-induced nephropathy in patients with stable coronary artery disease undergoing PCI?
Cohort (n=440)
Does increased aortic stiffness predict contrast-induced nephropathy in patients with stable coronary artery disease undergoing PCI?
Pre-procedural assessment of aortic stiffness using pulse wave velocity can help predict the development of contrast-induced nephropathy in patients undergoing PCI.
Answers are grounded in this paper and cite their sources.
May support pre-PCI CIN risk stratification in stable CAD; hypothesis-generating and requires prospective validation before practice change.
Increased aortic stiffness (AS) has been shown to be an independent risk factor for cardiovascular disease in renal failure and was also found to be associated with even mild renal insufficiency. We investigated the relationship between contrast-induced nephropathy (CIN) and AS parameters such as pulse wave velocity (PWV) and augmentation index (AIx). Patients (n = 440) with stable coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) were included prospectively (mean age: 60.3 ± 10.3 years). The PWV and AIx were calculated using the single-point method. The PWV, age, diabetes, SYNTAX score, and contrast media dose were independent predictors for CIN (P < .05, for all). The cutoff value for PWV obtained by the receiver-operator characteristic curve analysis was 10.35 m/s for the prediction of CIN (95% confidence interval: 0.838-0.916, sensitivity: 82.1%, specificity: 77.9%, and P < .001). In conclusion, a greater AS pre-PCI may predict CIN development in patients with stable CAD.
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Uçar et al. (2013) conducted a cohort in Stable coronary artery disease (n=440). Increased aortic stiffness (pulse wave velocity) was evaluated on Contrast-induced nephropathy (CIN) (95% CI 0.838-0.916, p=<.001). A pulse wave velocity cutoff of 10.35 m/s predicted contrast-induced nephropathy in stable CAD patients undergoing PCI (sensitivity 82.1%, specificity 77.9%, P<.001).
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