Key result
Aortic valve sclerosis was an independent predictor of contrast-induced nephropathy in patients with acute coronary syndrome undergoing percutaneous coronary intervention (OR 2.223, p=0.027).
Why the study?
Aortic valve sclerosis is closely related to endothelial dysfunction, but its association with contrast-induced nephropathy was unknown.
Does aortic valve sclerosis predict contrast-induced nephropathy in patients with acute coronary syndrome undergoing percutaneous coronary intervention?
Observational (n=292)
Does aortic valve sclerosis predict contrast-induced nephropathy in patients with acute coronary syndrome undergoing percutaneous coronary intervention?
Answers are grounded in this paper and cite their sources.
Aortic valve sclerosis is an independent predictor of contrast-induced nephropathy in ACS patients undergoing PCI, which may help identify high-risk patients for preventive measures.
Objective. Aortic valve sclerosis (AVS) is closely related to endothelial dysfunction. The association of AVS with contrast-induced nephropathy (CIN) is unknown. We planned to investigate the relationship of AVS besides known parameters with CIN. Design. Baseline characteristics, biochemical values, and AVS of 292 consecutive patients with acute coronary syndrome (ACS) that underwent percutaneous coronary intervention (PCI) were analyzed. Results. Fifty-three patients (18.2%) had CIN. Patients with CIN were older, less likely to be smokers, and had more prevalent prior bypass surgery, higher Mehran score, creatinine, and uric acid concentrations than those without CIN. AVS was more prevalent in patients with CIN. Logistic regression analysis including all related parameters identified Mehran score (OR = 1.036, p = .033), uric acid concentration (OR = 1.244, p = .023), and AVS (OR: 2.223, p = .027) as independent predictors of CIN. Conclusion. AVS is independently associated with CIN in patients with acute coronary syndrome undergoing percutaneous coronary intervention. AVS may help to identify high-risk patients for CIN, who would benefit from preventive measures.
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Durak et al. (2020) conducted an observational in Acute coronary syndrome (n=292). Aortic valve sclerosis vs. Absence of aortic valve sclerosis was evaluated on Contrast-induced nephropathy (CIN) (OR 2.223, p=0.027). Aortic valve sclerosis was an independent predictor of contrast-induced nephropathy in patients with acute coronary syndrome undergoing percutaneous coronary intervention (OR 2.223, p=0.027).
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