Key result
Perioperative milrinone use was independently associated with an increased risk of postoperative atrial fibrillation after elective cardiac surgery (OR 4.86; 95% CI 2.31 to 10.25; P<0.001).
Why the study?
Does milrinone use increase the risk of postoperative atrial fibrillation in patients undergoing elective cardiac surgery?
Population
232 patients who underwent elective cardiac surgery and were in sinus rhythm at surgery
Comparison
Milrinone use (perioperative) vs Nonusers of milrinone
Design
Cohort
Authors
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Should not yet change perioperative milrinone use; leaves open causality of postoperative AF in elective cardiac surgery.
Cohort (n=232)
Does milrinone use increase the risk of postoperative atrial fibrillation in patients undergoing elective cardiac surgery?
Odds Ratio: 4.86 (95% CI 2.31–10.25)
Absolute Event Rate: 58.2% vs 26.1%
p-value: p=<0.001
Perioperative use of milrinone during elective cardiac surgery is independently associated with a nearly five-fold increased odds of developing postoperative atrial fibrillation.
Fleming et al. (2008) conducted a cohort in Elective cardiac surgery (n=232). Milrinone use vs. Nonusers was evaluated on Postoperative atrial fibrillation (OR 4.86, 95% CI 2.31 to 10.25, p=<0.001). Perioperative milrinone use was independently associated with an increased risk of postoperative atrial fibrillation after elective cardiac surgery (OR 4.86; 95% CI 2.31 to 10.25; P<0.001).
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