Why the study?
Does chronic intracerebroventricular administration of metoprolol attenuate the progression of left ventricular remodeling in a rat model of myocardial infarction-induced heart failure?
Population
Rat model of myocardial infarction-induced heart failure
Design
Preclinical
Key result
Chronic intracerebroventricular administration of metoprolol attenuated the progression of left ventricular remodeling in a rat model of myocardial infarction-induced heart failure.
Authors
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Should not change practice; hypothesis-generating for central actions of lipophilic beta-blockers in human heart failure remodeling.
Does chronic intracerebroventricular administration of metoprolol attenuate the progression of left ventricular remodeling in a rat model of myocardial infarction-induced heart failure?
This study provides the first direct evidence that the central nervous system action of lipophilic beta-blockers contributes to their beneficial effects on left ventricular remodeling in heart failure.
Gourine et al. (2008) studied myocardial infarction-induced heart failure. metoprolol (intracerebroventricular administration) was evaluated on progression of left ventricular remodeling. Chronic intracerebroventricular administration of metoprolol attenuated the progression of left ventricular remodeling in a rat model of myocardial infarction-induced heart failure.