What is the clinical evidence from this study?

Study design: Review. Population: Oral anticoagulant control. Intervention: International Normalized Ratio (INR).

What question did this study set out to answer?

To establish a standardized international calibration framework for measuring prothrombin time during oral anticoagulant therapy.

April 21, 2009Haemostasis

Standardization of the Prothrombin Time in Oral Anticoagulant Control

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Key result

The International Normalized Ratio (INR) provides a universal scale for oral anticoagulation intensity, facilitating safe patient care and consensus on therapeutic ranges.

Design

Review

Authors

ABA.M.H.P. van den BesselaarLeiden University Medical Center

Discussion

Member takes

Implication

Enables standardized INR monitoring for safer anticoagulation care; leaves open refinement of ranges in emerging therapies.

Key Points

To establish a standardized international calibration framework for measuring prothrombin time during oral anticoagulant therapy.
Developed a calibration model utilizing International Reference Preparations for thromboplastin alongside instrument-specific testing systems.
Estimated the imprecision of calculated International Normalized Ratios using empirical data from international collaborative studies and proficiency testing programs.
Normalized prothrombin times calculated with calibrated thromboplastin and instrument systems safely guide anticoagulant dosing in routine clinical practice.
Implementation of the International Normalized Ratio scale enables consensus on target therapeutic ranges and ensures continuity of care for mobile or traveling patients.

PICO

Population

Oral anticoagulant control

Intervention / Comparator

International Normalized Ratio (INR)

The establishment of the International Normalized Ratio (INR) provides a universal, standardized scale for monitoring the intensity of oral anticoagulation therapy.

Cite This Study

A.M.H.P. van den Besselaar (2009) conducted a review in Oral anticoagulant control. International Normalized Ratio (INR) was evaluated. The International Normalized Ratio (INR) provides a universal scale for oral anticoagulation intensity, facilitating safe patient care and consensus on therapeutic ranges.

synapsesocial.com/papers/6a859ff4c670f88be7ae728d https://doi.org/10.1159/000215159

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Standardization of the Prothrombin Time in Oral Anticoagulant Control

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Standardization of the Prothrombin Time in Oral Anticoagulant Control

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Also Consider

Also Consider