April 9, 2005Molecular TherapyOpen Access

Widespread and early myocardial gene expression by adeno-associated virus vector type 6 with a β-actin hybrid promoter

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Why the study?

Does AAV6 vector improve the distribution and rapidity of myocardial gene expression compared to AAV2 vector in rat hearts?

Population

Rat hearts in vivo

Comparison

AAV pseudotype 6 vector delivering an alkaline… vs Standard serotype 2 vector delivering the same…

Design

Preclinical

Follow-up

7 days

Authors

SKShunsuke KawamotoNihon University QSQun ShiFoshan University YNYoshio NittaSendai Medical Center

Discussion

Member takes

Implication

AAV6 may enhance myocardial transduction in rodent models; leaves open translation to larger species or clinical gene therapy.

Structured PICO

Does AAV6 vector improve the distribution and rapidity of myocardial gene expression compared to AAV2 vector in rat hearts?

Population

Rat hearts in vivo

Intervention

AAV pseudotype 6 (AAV6) vector delivering an alkaline phosphatase (AP) reporter construct driven by the chicken beta-actin promoter via direct injection

Comparator

Standard serotype 2 (AAV2) vector delivering the same construct

Outcome

Amplitude of AP activity and transduced myocardial volumesurrogate

AAV6 vectors provide significantly earlier and more widespread myocardial gene expression compared to AAV2 vectors in rat models, showing potential for acute cardiac disease gene therapy.

Cite This Study

Kawamoto et al. (2005) studied this question.

synapsesocial.com/papers/6a85a37402a1bc3ea31e6d5e https://doi.org/10.1016/j.ymthe.2005.02.009

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Widespread and early myocardial gene expression by adeno-associated virus vector type 6 with a β-actin hybrid promoter

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Widespread and early myocardial gene expression by adeno-associated virus vector type 6 with a β-actin hybrid promoter

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider