Key result
ET-receptor blockade with tezosentan prevented the plateau of pulmonary blood flow and pulmonary vascular resistance compared with controls at 3 and 4 hours (P<0.05).
Population
20 lambs undergoing placement of an aortopulmonary vascular graft to acutely increase pulmonary blood flow
Comparison
Infusion of tezosentan or Nomega-nitro-L-arginine… vs Infusion of saline before and after shunt opening
Design
Preclinical
Follow-up
4 hours
Authors
Loading...
Tezosentan effects in this lamb model should not guide therapy; leaves open endothelin-NO interactions in human pulmonary vascular disease.
p-value: p=<0.05
In a lamb model of surgically increased pulmonary blood flow, endothelin-1 limits pulmonary vasodilation by decreasing nitric oxide synthase activity, highlighting the importance of NO in maintaining reduced pulmonary vascular resistance.
Oishi et al. (2005) studied Surgically induced acute increases in pulmonary blood flow (n=20). Tezosentan or Nomega-nitro-L-arginine (L-NNA) vs. Saline was evaluated on Pulmonary vascular resistance (PVR) and pulmonary blood flow (PBF) (p=<0.05). ET-receptor blockade with tezosentan prevented the plateau of pulmonary blood flow and pulmonary vascular resistance compared with controls at 3 and 4 hours (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: