Why the study?
Do cytokines (IL-1 beta, IL-6, TNF-alpha) directly inhibit the IGF-I mRNA response to growth hormone in rat primary cultured hepatocytes?
Population
Rat primary cultured hepatocytes isolated by liver collagenase perfusion and cultured on Matrigel
Comparison
Interleukin-1 beta, IL-6, and tumor necrosis… vs Control (absence of cytokines or growth hormone)
Design
Preclinical
Follow-up
24 hours
Authors
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May mediate low IGF-I in infection and trauma; leaves open relevance to human GH resistance.
Do cytokines (IL-1 beta, IL-6, TNF-alpha) directly inhibit the IGF-I mRNA response to growth hormone in rat primary cultured hepatocytes?
IL-1 beta and TNF-alpha directly blunt the IGF-I mRNA response to growth hormone at the hepatocyte level, suggesting a mechanism for decreased circulating IGF-I during infection and trauma.
Thissen et al. (1997) studied this question.
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