January 1, 2001EndocrinologyOpen Access

Interleukin-6 Stimulates Hepatic Insulin-Like Growth Factor Binding Protein-4 Messenger Ribonucleic Acid and Protein**This work was supported by grants from the Fund for Scientific Medical Research (Belgium), from the Fonds Speciaux de Recherche (Universite Catholique de Louvain, UCL) and from the Danone Institute (Brussels).

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Why the study?

Does IL-6 stimulate hepatic IGFBP-4 gene expression and production in rat models?

Population

Rat primary cultured hepatocytes and in vivo rat models

Comparison

Interleukin-6, with or without IL-1beta… vs Control/baseline or IL-6 alone

Design

Preclinical

Follow-up

24 h (in vitro)

Authors

LFLaura Fernández-Celemı́nEuropean Food Information Council JTJean‐Paul ThissenCliniques Universitaires Saint-Luc

Discussion

Member takes

Implication

IL-6 induction of hepatic IGFBP-4 may link inflammation to IGF-I regulation in sepsis; leaves open human relevance.

Structured PICO

Does IL-6 stimulate hepatic IGFBP-4 gene expression and production in rat models?

Population

Rat primary cultured hepatocytes and in vivo rat models

Intervention

Interleukin-6 (IL-6), with or without IL-1beta, TNF-alpha, dexamethasone, actinomycin, or cycloheximide

Comparator

Control/baseline or IL-6 alone

Outcome

IGFBP-4 messenger RNA (mRNA) and protein levelssurrogate

IL-6 stimulates hepatic IGFBP-4 gene expression and production, suggesting a mechanism by which proinflammatory cytokines may control IGF-I action during sepsis.

Cite This Study

Fernández-Celemı́n et al. (2001) studied this question.

synapsesocial.com/papers/6a7567a81646b2abe5036e8b https://doi.org/10.1210/endo.142.1.7903

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Discussion

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Implication

Structured PICO

Cite This Study

Discussion

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Implication

Structured PICO

Cite This Study

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