Key result
BNP concentration showed a more responsive decrease from admission (-54.1% at 72 hours) compared to NT-proBNP (-17.6% at 72 hours) in patients treated for acute decompensated heart failure.
Why the study?
Do BNP and NT-proBNP plasma concentration profiles differ in response to acute decompensated heart failure treatment in the emergency department?
Observational (n=42)
Do BNP and NT-proBNP plasma concentration profiles differ in response to acute decompensated heart failure treatment in the emergency department?
BNP may serve as a more sensitive marker than NT-proBNP for early stabilization in response to acute decompensated heart failure therapy due to its faster kinetic response.
Answers are grounded in this paper and cite their sources.
BNP may track early response more sensitively than NT-proBNP in acute HF; leaves open whether it should guide therapy.
Brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are currently used for the diagnosis, prognosis, and therapeutic decision making in heart failure patients. The aim of the study was to compare BNP and NT-proBNP plasma concentration profiles in 42 patients with decompensated heart failure who underwent treatment in the emergency department. A significant decrease in both peptide concentrations fell beyond 24 hours of therapy. BNP concentration underwent a more responsive change from admission (-54.1%+/-8.6% at 72 hours and -57.4%+/-7.6% at discharge) than NT-proBNP concentration (-17.6%+/-5.4% at 72 hours and -18.6%+/-5.6% at discharge). Although BNP and NT-proBNP concentrations were highly correlated, no correlation in their variations was found, a finding that suggests a different kinetic behavior in response to treatment. Sequential measurements of BNP and NT-proBNP provide a reliable marker to confirm clinical improvement after 24 hours of treatment. BNP may show some advantages over NT-proBNP as a more sensitive marker of early stabilization in response to therapy.
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Somma et al. (2008) conducted an observational in Decompensated heart failure (n=42). BNP concentration profile vs. NT-proBNP concentration profile was evaluated on Change in plasma concentration from admission at 72 hours. BNP concentration showed a more responsive decrease from admission (-54.1% at 72 hours) compared to NT-proBNP (-17.6% at 72 hours) in patients treated for acute decompensated heart failure.
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