Why the study?
Does central angiotensin AT1 receptor blockade impair thermoregulation and water intake in rats exposed to heat?
Population
Rats (n=11)
Comparison
Intracerebroventricular injection of 10 microg… vs Intracerebroventricular injection of artificial…
Design
Preclinical
Follow-up
180 minutes
Authors
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AT1 blockade impairs thermoregulation and drinking in heat-exposed rats; leaves open translation to humans or ARB safety.
Does central angiotensin AT1 receptor blockade impair thermoregulation and water intake in rats exposed to heat?
Central angiotensin AT1 receptor blockade impairs thermoregulatory cooling and subsequent water intake in heat-exposed rats, indicating a role for central angiotensinergic mechanisms in these responses.
Mathai et al. (2000) studied this question.
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