October 1, 1996Regulatory PeptidesOpen Access

Blockade of central angiotensin II type 1 and type 2 receptors suppresses adrenalectomy-induced NaCl intake in rats

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Structured PICO

Population

Adrenalectomized rats

Intervention

Intracerebroventricular injection of specific antagonists of Ang II type 1 (AT1) (losartan) or type 2 (AT2) (PD 123319) receptors, alone or in combination

Outcome

Adrenalectomy-induced NaCl intakesurrogate

Central AT1 receptors mediate the natriorexigenic effect of Ang II, with AT2 receptors playing a permissive role in adrenalectomized rats.

Discussion

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Implication

Should not inform clinical sodium intake management; leaves open combined AT1/AT2 antagonism mechanisms in adrenalectomized models.

Cite This Study

Galaverna et al. (1996) studied this question.

synapsesocial.com/papers/6a85b6f24f2eb4dbc91e6bb1 https://doi.org/10.1016/0167-0115(96)00062-6

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