Key result
Angiotensin II protected cardiac fibroblasts from IL-1beta-induced apoptosis by downregulating iNOS expression and activating the phosphatidylinositol 3-kinase-Akt survival pathway.
Angiotensin II protects cardiac fibroblasts from nitric oxide-induced apoptosis via AT1 receptor activation and the PI3K-Akt survival pathway, suggesting a role in regulating cell population size.
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Should not change clinical practice; leaves open the pathway's role in human cardiac remodeling.
Tian et al. (2003) studied Cardiac fibroblast apoptosis. Angiotensin II was evaluated on Cardiac fibroblast apoptosis. Angiotensin II protected cardiac fibroblasts from IL-1beta-induced apoptosis by downregulating iNOS expression and activating the phosphatidylinositol 3-kinase-Akt survival pathway.
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